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  • Efectos antitumorales (miscelánea)

    Diversos estudios han mostrado actividad en diversos tumores, como en el hepatoma1-2, esporas de Ganoderma lucidum mostraron, sobre la línea celular humana de hepatoma (HepG2), que inhibían la proliferación celular y el crecimiento del tumor actuando sobre el ciclo de reproducción y que en grandes dosis inducía a la apoptosis3. En cáncer de vejiga4-5 y, sobre todo en neoplasias hematológicas como leucemia, mieloma y linfoma6-8, tanto in Vitro como in vivo e incluso en seres humanos9.

    1-    Lin SB, Li CH, Lee S et als. Triterpene- enriched extracts from Ganoderma lucidum inhibit growth of hepatoma cells via suppressing protein kinase C, activating mitogen-activated protein kinases and G2-phase cell cycle arrest. Life Sci 2003; 72:2381-90

    2-    Weng CJ, Chau CF, Hsie YS et als. Lucidenic acid inhibits PMA-induced invasion of human hepatoma cells through inactivating MAPK/ERK signal transduction pathway an reducing binding activities of NF-kappaB and AP-1. Carcinogenesis 2008; 29:147-56

    3-    Li L, Li T, Wang XJ et als. Effects of Ganoderma lucidum spores on HepG2 cells proliferation and growth cycle. Zhong Yao Cai 2008; 31:1514-8

    4-    Lu QY, Jin YS, Zhang Z et als. Ganoderma lucidum extracts inhibit growth and induce actin polymerization in bladder cancer cells in vitro. Cancer Lett. 2004; 216:9-20

    5-    Yuen JW, Gohel MD and Au DW. Telomerase-associated apoptotic events by mushroom ganoderma lucidum on premalignant huan urothelial cells. Nutr Cancer 2008; 60:109-19

    6-    Muller CI, Kumagai T, O’Kelly J et als. Ganoderma lucidum causes apoptosis in leukaemia, linfoma and multiple myeloma cells. Leuk Res 2006; 30:767-8

    7-    Cheng KC, Huang HC, Chen JH et als. Ganoderma lucidum polysaccharides in human leukaemia cells: from gene expression to network construction. BMC Genomics 2007; 9:411

    8-    Kim KC, Kim JS, Son JK et als. Enhance induction of mitochondrial damage and apoptosis in human leukaemia HL-60 cells by Ganoderma lucidum and Duchesnea chrysantha extracts. Cancer Lett 2007; 210-7

    9-    Cheuk W, Chan JK, Nuovo G et als. Regression of gastric large B-Cell lymphoma-like  T-cell reaction: immunomodulatory effect of ganoderma lucidum? Int J Surg Pathol 2007; 15:180-6

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